Platelet-to-lymphocyte ratio in early onset neonatal

Objectives Neonatal sepsis is a major contributor to morbidity and mortality worldwide. Although blood culture the gold standard of diagnosis, it often lacks sensitivity diagnostic speed. Platelet-to-lymphocyte ratio (PLR) widely available, effective, simple, affordable marker that can predict early onset neonatal (EONS).
 Objective To assess correlation between PLR EONS as well value for predicting EONS.
 Methods This study included all inpatient neonates with suspected early-onset at Dr. R. D. Kandou Hospital, Manado, North Sulawesi, Indonesia. Neonates were categorized into (confirmed by positive results) non-sepsis (negative groups. Bivariate analysis, including chi-square test categorical data independent t-test numerical data, was performed identify any significant associations platelet-to-lymphocyte EONS. The sensitivity, specificity, area under receiver operating characteristic (ROC) curve calculated determine optimal cut-off point Results In this study, we investigated relationship (EONS) in 176 Blood cultures confirmed 84 (47.7%), Klebsiella pneumoniae being most common causative organism. We found (p<0.001), 61.806 identified high (90.2%) specificity (85.7%)
 Conclusion Our demonstrates strong EONS, be used valuable sepsis. These findings could aid identification treatment sepsis, ultimately improving patient outcomes.